Respiratory Vaccine

Respiratory Vaccine

Background:

Respiratory syncytial virus (RSV) is the leading cause of viral lower respiratory tract illness in infants and children and is an important cause of lower respiratory tract illness in other populations. Despite decades of research there are currently no licensed vaccines for prevention of RSV disease.

Methods:

A review of the obstacles to RSV vaccine development; current live, attenuated and subunit RSV vaccines in clinical development; and the potential for developing additional vaccine candidates based on recombinant technology.

Results:

A number of biologically derived live attenuated RSV vaccines were evaluated in Phase I clinical trials in adults and children, and one vaccine (cpts 248/404) was evaluated in infants as young as 1 month of age. These vaccines displayed a spectrum of attenuation, with cpts 248/955 being the least attenuated and cpts 248/404 being the most attenuated candidate vaccine. None of these was sufficiently attenuated for young infants. The ability to generate recombinant RSV vaccines has led to the development of large numbers of candidate vaccines containing combinations of known attenuating point mutations and deletions of nonessential genes. Clinical evaluation of many of these candidates is in progress. Three types of RSV subunit vaccines have recently been evaluated in clinical trials: purified F glycoprotein vaccines (PFP-1, PFP-2 and PFP-3), BBG2Na and copurified F, G and M proteins. Additional studies of the F/G/M protein vaccine are being conducted.

1.Flu vaccine- Influenza (H1N1) to be given every year before monsoon preferebly in September or October for all 50 years age and above and less than 5 with chronic diseases like Diabetes, COPD,Asthma, chronic heart disease, CKD , Chronic liver disease and cancer disease and Rhuematological disease.

2. Pneumococcal vaccine- 2 types of vaccine one conjugate vaccine other one is polysaccharide vaccine. As per the recommendation one shot of polysaccharide vaccine and same injection as boostr after 5 years. Certain selective patients like CKD and organ transplantation first conjugate vaccine after 6 months polysaccharide vaccine and booster polysaccharide vaccine after 5 years.